5-Bullet Friday — Real One-Person Billion-Dollar Companies, Producing Five Psychedelics from One Plant, Wisdom from Samurai, and Inventors Who Think Big
2026-04-036 min read1,160 wordsgeneric
“One should make his decisions within the space of seven breaths.”
Here is your weekly dose of 5-Bullet Friday, a list of what I’m pondering and exploring.
This edition is brought to you by Our Place, makers of the Titanium Always Pan Pro, my go-to cooking pan. Most nonstick pans can release PFAS, also referred to as “forever chemicals,” and I prefer to dodge the toxins. Read more in the P.S.
From his house in Los Angeles, Mr. Gallagher, 41, used A.I. to write the code for the software that powers his company, produce the website copy, generate the images and videos for ads and handle customer service. He created A.I. systems to analyze his business’s performance. And he outsourced the other stuff he couldn’t do himself.
His start-up, Medvi, a telehealth provider of GLP-1 weight-loss drugs, got 300 customers in its first month. In its second month, it gained 1,000 more. In 2025, Medvi’s first full year in business, the company generated $401 million in sales.
Mr. Gallagher then hired his only employee, his younger brother, Elliot. This year, they are on track to do $1.8 billion in sales.
**The Big Sick**. If you’re looking for a very funny and smart movie, this is what the doctor ordered (pun intended). It scores 98% on Rotten Tomatoes’ Tomatometer. Here’s the description: “The Big Sick is based on the real-life courtship between Pakistan-born comedian Kumail Nanjiani and Emily Gordon, who fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family’s expectations, and his true feelings.” I found this movie while looking for the best comedy screenplays online, which took me to this page.
Book excerpt I’m pondering
“‘If Thinking Big accomplishes so much, why doesn’t everyone think that way?’ I’ve been asked that question many times. Here, I believe, is the answer. All of us, more than we recognize, are products of the thinking around us. And much of this thinking is little, not big.” — From The Magic of Thinking Big by David J. Schwartz. For more on Stephen Key, the amazing inventor who introduced me to Schwartz’s book, check out “A Beginner’s Guide: How to Rent Your Ideas to Fortune 500 Companies.”
Quote I’m pondering
“In the words of the ancients, one should make his decisions within the space of seven breaths. Lord Takanobu said, ‘If discrimination is long, it will spoil.’ Lord Naoshige said, ‘When matters are done leisurely, seven out of ten will turn out badly. A warrior is a person who does things quickly.’ When your mind is going hither and thither, discrimination will never be brought to a conclusion. With an intense, fresh and undelaying spirit, one will make his judgments within the space of seven breaths. It is a matter of being determined and having the spirit to break right through to the other side.” —Yamamoto Tsunetomo, Japanese samurai and writer
And, as always, please give me feedback on X. Which bullet above is your favorite? What do you want more or less of? Other suggestions? Please let me know. Just send a tweet to @tferriss and put #5BulletFriday at the end so I can find it.
Many nonstick pans can release harmful “forever chemicals”—PFAS—into your food, home, and, ultimately, your body. Teflon is an example; it is the forever chemical that most companies are still using. Exposure to PFAS has been linked to health issues like gut microbiome disruption, testosterone dysregulation, and more, which have been correlated to chronic disease in the long term. This is why I use the**Titanium Always Pan Pro**from Our Place. It’s the first nonstick pan with zero coating. This means zero “forever chemicals” and durability that will last a lifetime. There is no degradation over time, unlike traditional nonstick pans.
Our Place expanded the lineup and launched the Titanium Pro Cookware Set—a toxin-free, high-performance set designed to last a lifetime. It’s built on the success of the Titanium Always Pan Pro. You can cook everything with the same health-first, long-lasting design. Stop cooking with toxic cookware, and upgrade to Our Place today. **Our Place**is having their biggest sale of the season:**save between 10% and 40% sitewide now through April 12th**. With a hundred-day risk-free trial plus free shipping and returns, you can experience this game-changing cookware with zero risk.
The Tim Ferriss Show is one of the most popular podcasts in the world with more than one billion downloads. It has been selected for "Best of Apple Podcasts" three times, it is often the #1 interview podcast across all of Apple Podcasts, and it's been ranked #1 out of 400,000+ podcasts on many occasions.
DO NOT REPLY HERE: Due to volume, please do not reply to this email. Sadly we are unable to read 1000+ email replies daily. To reply to Tim, please do so in the blog comments here.
3112 Windsor Rd., Box #UNS, Austin TX 78703, United States
# 5-Bullet Friday — Real One-Person Billion-Dollar Companies, Producing Five Psychedelics from One Plant, Wisdom from Samurai, and Inventors Who Think Big
“One should make his decisions within the space of seven breaths.”
# 5-Bullet Friday
The latest from author and investor [Tim Ferriss](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/p8heh9h46ork7rbq/aHR0cHM6Ly90aW0uYmxvZy8=)
Hi All!
Here is your weekly dose of _5-Bullet Friday_, a list of what I’m pondering and exploring.
This edition is brought to you by Our Place, makers of the [Titanium Always Pan Pro](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=), my go-to cooking pan. Most nonstick pans can release PFAS, also referred to as “forever chemicals,” and I prefer to dodge the toxins. Read more in the P.S.
## **What I’m reading****“**[**How A.I. Helped One Man (and His Brother) Build a $1.8 Billion Company**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/6qheh8hlrexv2rfo/aHR0cHM6Ly93d3cubnl0aW1lcy5jb20vMjAyNi8wNC8wMi90ZWNobm9sb2d5L2FpLWJpbGxpb24tZG9sbGFyLWNvbXBhbnktbWVkdmkuaHRtbA==)**.”** (_The New York Times_).
_From his house in Los Angeles, Mr. Gallagher, 41, used A.I. to write the code for the software that powers his company, produce the website copy, generate the images and videos for ads and handle customer service. He created A.I. systems to analyze his business’s performance. And he outsourced the other stuff he couldn’t do himself._
_His start-up, Medvi, a telehealth provider of GLP-1 weight-loss drugs, got 300 customers in its first month. In its second month, it gained 1,000 more. In 2025, Medvi’s first full year in business, the company generated $401 million in sales._
_Mr. Gallagher then hired his only employee, his younger brother, Elliot. This year, they are on track to do $1.8 billion in sales._
## **Article and science I’m tracking****“**[**Tobacco plant altered to produce five psychedelic drugs**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/kkhmh6hnwvzg9vil/aHR0cHM6Ly93d3cubmV3c2NpZW50aXN0LmNvbS9hcnRpY2xlLzI1MjEzMzgtdG9iYWNjby1wbGFudC1hbHRlcmVkLXRvLXByb2R1Y2UtZml2ZS1wc3ljaGVkZWxpYy1kcnVncy8=)**”** (_New Scientist_). Scientists at the [Weizmann Institute](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/58hvh7hgx23p98i6/aHR0cHM6Ly9lbi53aWtpcGVkaWEub3JnL3dpa2kvV2Vpem1hbm5fSW5zdGl0dXRlX29mX1NjaWVuY2U=) genetically engineered a single tobacco plant to produce five psychedelic compounds—including psilocybin, DMT, and 5-MeO-DMT—using a technique that temporarily introduces genes from mushrooms, plants, and even the Colorado River toad. The approach could offer a simpler, more sustainable alternative to chemical synthesis for producing psychedelics for therapeutic research.For pairing and background, you can read my older article titled “[An Urgent Plea to Users of Psychedelics: Let’s Consider a More Ethical Menu of Plants and Compounds](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/25h2hoh39wlroph3/aHR0cHM6Ly90aW0uYmxvZy8yMDIxLzAyLzIxL3VyZ2VudC1wbGVhLXVzZXJzLW9mLXBzeWNoZWRlbGljcy1ldGhpY2FsLXBsYW50cy1jb21wb3VuZHMvP3V0bV9jYW1wYWlnbj01YmYmdXRtX21lZGl1bT1jb252ZXJ0a2l0JnV0bV9zb3VyY2U9Y29udmVydGtpdA==).”
## **What I’m watching**
[**_The Big Sick_**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/qvh8h7hdwpeg69il/aHR0cHM6Ly93d3cuYW1hem9uLmNvbS9CaWctU2ljay1LdW1haWwtTmFuamlhbmkvZHAvQjA4OVhZQkxKVi8%5FdGFnPW9mZnNpdG9mdGltZmUtMjA=)**.** If you’re looking for a very funny and smart movie, this is what the doctor ordered (pun intended). It scores 98% on Rotten Tomatoes’ Tomatometer. Here’s the description: “_The Big Sick_ is based on the real-life courtship between Pakistan-born comedian [Kumail Nanjiani](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/g3hnh5hm9wg7zqcr/aHR0cHM6Ly9lbi53aWtpcGVkaWEub3JnL3dpa2kvS3VtYWlsX05hbmppYW5p) and [Emily Gordon](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/9qhzhnhdwr4k2et9/aHR0cHM6Ly9lbi53aWtpcGVkaWEub3JnL3dpa2kvRW1pbHlfVi5fR29yZG9u), who fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family’s expectations, and his true feelings.” I found this movie while looking for the best comedy screenplays online, which took me to [this page](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/3ohphkh3mgx6d8tr/aHR0cHM6Ly93d3cuc2NyaXB0cmVhZGVycHJvLmNvbS9iZXN0LWNvbWVkeS1zY3JpcHRzLw==).
## **Book excerpt I’m pondering****“‘If Thinking Big accomplishes so much, why doesn’t everyone think that way?’ I’ve been asked that question many times. Here, I believe, is the answer. All of us, more than we recognize, are products of the thinking around us. And much of this thinking is little, not big.”**
— From [_The Magic of Thinking Big_](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/n2hohvhvq02wodu6/aHR0cHM6Ly93d3cuYW1hem9uLmNvbS9NYWdpYy1UaGlua2luZy1CaWctU2VjcmV0LVN1Y2Nlc3MvZHAvMDU5MzcxMzIzMC8%5FdGFnPW9mZnNpdG9mdGltZmUtMjA=) by [David J. Schwartz](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/48hvhehml8wz0zhx/aHR0cHM6Ly9lbi53aWtpcGVkaWEub3JnL3dpa2kvRGF2aWRfSi5fU2Nod2FydHpfKG1vdGl2YXRpb25hbF93cml0ZXIp). For more on Stephen Key, the amazing inventor who introduced me to Schwartz’s book, check out “[A Beginner’s Guide: How to Rent Your Ideas to Fortune 500 Companies](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/wnh2hghq76m9r5s7/aHR0cHM6Ly90aW0uYmxvZy8yMDA3LzExLzI2L2EtYmVnaW5uZXJzLWd1aWRlLWhvdy10by1yZW50LXlvdXItaWRlYXMtdG8tZm9ydHVuZS01MDAtY29tcGFuaWVzLXBsdXMtdmlkZW8vP3V0bV9jYW1wYWlnbj01YmYmdXRtX21lZGl1bT1jb252ZXJ0a2l0JnV0bV9zb3VyY2U9Y29udmVydGtpdA==).”
## **Quote I’m pondering****“In the words of the ancients, one should make his decisions within the space of seven breaths. Lord Takanobu said, ‘If discrimination is long, it will spoil.’ Lord Naoshige said, ‘When matters are done leisurely, seven out of ten will turn out badly. A warrior is a person who does things quickly.’ When your mind is going hither and thither, discrimination will never be brought to a conclusion. With an intense, fresh and undelaying spirit, one will make his judgments within the space of seven breaths. It is a matter of being determined and having the spirit to break right through to the other side.”**
—[Yamamoto Tsunetomo](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/reh8hohmdzk9q3i2/aHR0cHM6Ly9lbi53aWtpcGVkaWEub3JnL3dpa2kvWWFtYW1vdG9fVHN1bmV0b21v), Japanese samurai and writer
You can complement this edition of _5-Bullet Friday_ with [my podcast episode on “The Fundamental Four,”](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/08hwh9h2ern0mxfl/aHR0cHM6Ly90aW0uYmxvZy8yMDE5LzEyLzA5L3RpbS1mZXJyaXNzLXJlY29tbWVuZGVkLWJvb2tzLz91dG1fY2FtcGFpZ249NWJmJnV0bV9tZWRpdW09Y29udmVydGtpdCZ1dG1fc291cmNlPWNvbnZlcnRraXQ=) the books I had originally recommended in the back of [_The 4-Hour Workweek_](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/8ghqhohodnwegpuk/aHR0cHM6Ly93d3cuYW1hem9uLmNvbS80LUhvdXItV29ya3dlZWstRXNjYXBlLUxpdmUtQW55d2hlcmUvZHAvMDMwNzQ2NTM1Ny8%5FdGFnPW9mZnNpdG9mdGltZmUtMjA=).
And, as always, please give me feedback on X. Which bullet above is your favorite? What do you want more or less of? Other suggestions? Please let me know. Just [send a tweet to @tferriss](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/vqh3hrho0rm2ndig/aHR0cHM6Ly90d2l0dGVyLmNvbS90ZmVycmlzcw==) and put #5BulletFriday at the end so I can find it.
Have a wonderful weekend, all.
Much love to you and yours,
Tim
## **P.S. Deal of the Week —** [**The Titanium Pro Cookware Set from Our Place**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=)**!**
Many nonstick pans can release harmful “forever chemicals”—PFAS—into your food, home, and, ultimately, your body. Teflon is an example; it is _the_ forever chemical that most companies are still using. Exposure to PFAS has been linked to health issues like gut microbiome disruption, testosterone dysregulation, and more, which have been correlated to chronic disease in the long term. **This is why I use the** [**Titanium Always Pan Pro**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=) **from Our Place.** It’s the first nonstick pan with zero coating. This means zero “forever chemicals” and durability that will last a lifetime. There is no degradation over time, unlike traditional nonstick pans.
Our Place expanded the lineup and launched the [Titanium Pro Cookware Set](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=)—a toxin-free, high-performance set designed to last a lifetime. It’s built on the success of the Titanium Always Pan Pro. You can cook everything with the same health-first, long-lasting design. Stop cooking with toxic cookware, and upgrade to Our Place today. [**Our Place**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=) **is having their biggest sale of the season:** [**save between 10% and 40% sitewide now through April 12th**](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/x0hph6he20k87ot5/aHR0cHM6Ly9mcm9tb3VycGxhY2UuY29tL3BhZ2VzL3RpbS1mZXJyaXNzP3V0bV9jYW1wYWlnbj1USU0tZW1haWwmdXRtX21lZGl1bT1wb2RjYXN0JnV0bV9zb3VyY2U9YXVkaW8=)**.** With a hundred-day risk-free trial plus free shipping and returns, you can experience this game-changing cookware with zero risk.
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## Tim Ferriss### Listen to _The Tim Ferriss Show_ Podcast
_The Tim Ferriss Show_ is one of the most popular podcasts in the world with more than one billion downloads. It has been selected for "Best of Apple Podcasts" three times, it is often the #1 interview podcast across all of Apple Podcasts, and it's been ranked #1 out of 400,000+ podcasts
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[ Podcasts ](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/m2h7h5h35z2kootm/aHR0cHM6Ly9pdHVuZXMuYXBwbGUuY29tL3VzL3BvZGNhc3QvdGhlLXRpbS1mZXJyaXNzLXNob3cvaWQ4NjM4OTc3OTU%5FbXQ9Mg==)
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[ Overcast ](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/dpheh0he6ndzq0bm/aHR0cHM6Ly9vdmVyY2FzdC5mbS9pdHVuZXM4NjM4OTc3OTUvdGhlLXRpbS1mZXJyaXNzLXNob3c=) [ Spotify ](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/e0hph7h7vom9k7u8/aHR0cHM6Ly9vcGVuLnNwb3RpZnkuY29tL3Nob3cvNXFTVXlDcms5S1I2OWxFaVhiandYTQ==) [ Tim's Blog](https://click.fourhourmail.com/r8ue2z059nhoh3z3q85h2hdnvzne0u7hzrx/7qh7h8h9l5dv0wuz/aHR0cHM6Ly90aW0uYmxvZy9wb2RjYXN0P3V0bV9jYW1wYWlnbj1kZXNpZ24tdGVzdCZ1dG1fbWVkaXVtPWNvbnZlcnRpdCZ1dG1fc291cmNlPWNvbnZlcnRraXQ=)
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